Identification of DNA G–quadruplex Forming Sequence in Shrimp White Spot Syndrome Virus (WSSV)

White spot syndrome virus (WSSV) is considered one of the most infectious and lethal viruses that affect shrimp. Bioinformatic studies revealed several G-quadruplex forming sequences at open reading frame region. Moreover, are widely conserved through all deposited WSSV sequences. Introductory structural on two sequences, namely WSSV131 WSSV172, proposed to form a quadruplex. While WSSV172 forms mixture quadruplex topologies, suggested parallel topology, as indicated by NMR spectra circular dichroism (CD) ellipticity pattern. CD also major species sequence found be stable above 60 °C. Ultimately, these results may new strategy for treatment targeting confirmation with binding ligand.